Changing teams for league expansion.

Apologies if this is in the wrong place.

Seeing as how Inter Miami and Nashville are set to join the MLS at a later date, would it be possible to create a team to replace either one of those teams and take their place in the MLS?

As the lower leagues in America are not playable, would it have any negative effect if Nashville didn't join the MLS? Miami are classed as a lower league team anyway and are, therefore, not even in a league.

I don't want to create a team to take the place of Miami or Nashville if it is going to cause problems down the line so I figured I'd ask first.